Lactic acid still remains the real cause of exercise-induced metabolic acidosis.
نویسندگان
چکیده
To the Editor: We appreciate the article of Robergs et al. (5), which gives a complete overview of the biochemistry of metabolic acidosis originating from intense muscular exercise. However, with the intention to clarify the causes of the pH decrease, the authors try to prove that lactic acid plays no role in this process and thus declare that generations of exercise physiologists have been using a false concept. We feel that this attempt results in confusion. A number of statements cannot be accepted:
منابع مشابه
Invited Review Biochemistry of exercise-induced metabolic acidosis
Robergs, Robert A., Farzenah Ghiasvand, and Daryl Parker. Biochemistry of exercise-induced metabolic acidosis. Am J Physiol Regul Integr Comp Physiol 287: R502–R516, 2004; 10.1152/ajpregu.00114.2004.—The development of acidosis during intense exercise has traditionally been explained by the increased production of lactic acid, causing the release of a proton and the formation of the acid salt s...
متن کاملBiochemistry of exercise-induced metabolic acidosis.
The development of acidosis during intense exercise has traditionally been explained by the increased production of lactic acid, causing the release of a proton and the formation of the acid salt sodium lactate. On the basis of this explanation, if the rate of lactate production is high enough, the cellular proton buffering capacity can be exceeded, resulting in a decrease in cellular pH. These...
متن کاملExercise-Induced Metabolic Acidosis
The widespread belief that intense exercise causes the production of “lactic acid” that contributes to acidosis is erroneous. In the breakdown of a glucose molecule to 2 pyruvate molecules, three reactions release a total of four protons, and one reaction consumes two protons. The conversion of 2 pyruvate to 2 lactate by lactate dehydrogenase (LDH) also consumes two protons. Thus lactate produc...
متن کاملLactate metabolism: a new paradigm for the third millennium.
For much of the 20th century, lactate was largely considered a dead-end waste product of glycolysis due to hypoxia, the primary cause of the O2 debt following exercise, a major cause of muscle fatigue, and a key factor in acidosis-induced tissue damage. Since the 1970s, a 'lactate revolution' has occurred. At present, we are in the midst of a lactate shuttle era; the lactate paradigm has shifte...
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BACKGROUND Frequent causes of high anion gap metabolic acidosis are well known: ethanol, methanol, and ethylene glycol intoxication; hyperglycemia; lactic or D-lactic acidosis; and impaired renal function. There are other causes, less frequent but also important. This report illustrates a rare case of a patient with increased anion gap metabolic acidosis due to a deficit of the γ-glutamyl cycle...
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ورودعنوان ژورنال:
- American journal of physiology. Regulatory, integrative and comparative physiology
دوره 289 3 شماره
صفحات -
تاریخ انتشار 2005